Animal, plant, human, fungal protein contaminated vaccines, heparin injections, biologics cause numerous autoimmune disorders including anti-PF4 antibodies
Reviewing the recent report on the investigation of COVID-19 vaccine-induced blood clots.
Researchers from Mayo Clinic and AstraZeneca recently reported their findings on the mechanisms involved in vaccine-induced immune thrombotic thrombocytopenia (VITT).
ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome
Heparin induced thrombocytopenia (HIT) is due to animal protein contamination of heparin injections (including porcine/bovine PF4). Heparin for injection is derived from porcine and bovine sources and is thus contaminated with porcine/bovine proteins (including PF4). As detailed below, with just a few amino acid residue differences compared to Platelet Factor 4 (PF4) epitopes involved in thrombocytopenia, porcine and bovine antigens are ideally suited to induce autoimmunity, leading to heparin induced thrombocytopenia.
Analyzing 23000+ epitopes covering 82 autoimmune diseases in the Immune Epitope Database, 57% have only one and 78% have up to two amino acid residue differences compared to animal, fungal or plant peptides present in vaccines; an unmistakable signature of the role of vaccines in their etiologies
The BLASTP match scores for bovine/porcine antigens compared to thrombocytopenia related, IEDB listed, PF4 epitopes, ranges from 26-46 compared to 19.7 BLASTP match score for the epitope that resulted in Pandemrix induced narcolepsy. Higher scores mean higher probability of cross-reaction.
It has been known for at least 45 years that immunization with homologous xenogeneic antigens results in abrogation of peripheral tolerance and induction of autoimmunity.
mRNA vaccines induce anti-PF4 autoantibodies too.
So even if their finding is correct, it is just one of multiple failure modes that induce anti-PF4 antibodies.
The authors wrote: "This confirms that the association between Vaxzevria and PF4 is an interaction between the PF4 and ChAdOx1, rather than any cell line–derived proteins remaining in the vaccine following manufacture. "
No. They cannot draw such a conclusion. Vaxzevria is contaminated with human/plant/animal proteins (including bovine PF4 due to fetal calf serum contamination of HEK cell culture used in manufacturing). All of them can induce anti-PF4 antibodies.
Natural adenovirus infection resulting in adenovirus interaction with PF4 is unlikely to cause anti-PF4 autoimmunity because of fail-safe mechanisms evolved over millions of years as Wraith et. al describe. Genetically modified viruses are another story as they defeat all that. I repeatedly warned AstraZeneca/Oxford Vaccine Group on the need for Failure Modes and Effects Analysis (FMEA) during vaccine development. They of course ignored me and now hundreds of lives have been lost to these dangerous vaccines.
https://publons.com/publon/33271973/#review-9015091
https://publons.com/publon/33747368/#review-9024531
The authors wrote: "This proposal goes some way toward explaining why TTS is observed so rarely, because it may require a series of low frequency stochastic interactions, first between small numbers of adenovirus particles entering the blood/lymph and then monocytes and/or B cells, which may only occur in individuals who are predisposed toward the generation of anti-PF4 antibodies."
That is all incorrect. 67% of the Vaxzevria recipients developed autoimmunity directed at PF4 which is just one contaminating protein in the vaccine. Nothing rare about it. There are ~2000 contaminating proteins in Vaxzevria. Thus guaranteeing that EVERY vaccine recipient will be injured. So at least 67% of patients who received the vaccine are ticking time-bombs for bleeding/clotting disorders. EVERYONE is "predisposed toward the generation of anti-PF4 antibodies" or other autoantibodies because that is part of the defense against cancer. So people who are "predisposed" are perfectly healthy and the adverse events they suffer as a result of these contaminated vaccines is no fault of theirs or their immune system.
The authors wrote: "If large immune complexes formed directly with components of the vaccine formulation, then it seems more likely that they would lead to platelet activation and clot formation immediately following vaccination, rather than >5 days later."
Since numerous pre-COVID vaccines, like Vaxzevria, are also contaminated with animal/plant/human/fungal proteins, ~7% of the population already are making anti-PF4 antibodies. So VITT/TTS can not only be due to de novo induction of PF4 autoimmunity by Vaxzevria but can also be a recall response to Vaxzevria following priming with a different vaccine.
These vaccines are unsafe and UNNECESSARY. We determined the root cause of COVID-19 severity. COVID-19 severity is an allergic reaction to the virus due to priming by Tdap, flu shot, etc.. Histamine H2/H1 blockers (famotidine/cetirizine), mast cell stabilizers (including SSRI) can address this problem. No vaccines were needed.
https://www.regulations.gov/document/FDA-2020-N-1898-0039
How were claims of "safe and effective" made for these vaccines when so little was understood, so little homework was done?