Pharma, New England Journal of Medicine, Brigham and Women's Hospital, Forbes and Amgen have declared war on vitamin D, to boost osteoporosis rates thus expanding the market for Amgen's romosozumab
While adequate vitamin D is important for reducing the risk of osteoporosis, boron is also important: https://aminotheory.com/cv19/#08-boron . Most people only get 1 mg or so boron a day, but 20 mg a day is safe for adults and 6 to 12 mg supplemental boron a day would probably significantly improve their bone health and help reduce excessive inflammation. Boron's biological mechanisms in mammals are not yet known.
The 30 ng/mL 25-hydroxyvitamin D target and 0.025 to 0.05 mg 1000 to 2000 IU a day intakes mentioned above might be sufficient for the kidneys to supply the very low level of hormonal 1,25-dihydroxyvitamin D (calcitriol) needed for proper calcium-phosphate-bone metabolism, but these are inadequate for the immune system's needs - 50 ng/mL circulating 25-hydroxyvitamin D is needed. The immune system is not affected by nor does it affect the hormonal 1,25-dihydroxyvitamin D.
Without proper supplementation, most people have only 5 to 25 ng/mL 25 hydroxyvitamin D, so their immune system's innate and adaptive responses are crippled - and they are at very high risk for wildly-dysregulated hyper-inflammatory responses.
For most 70 kg non-obese people, 0.125 mg 5000 IU vitamin D3 a day will attain at least 50 ng/mL 125 nmol/L after 3 months or so.
For rapid repletion of 25-hydroxyvitamin D in the event of COVID-19 or any other infection, 10 mg 400,000 IU vitamin D3 (for 70 kg BW) takes about 4 days to attain 50 ng/mL due to the need for hydroxylation in the liver. The best approach (again, 70 kg BW) is a single oral dose of 1 mg calcifediol (another name for 25-hydroxyvitamin D). This goes straight into circulation and raises levels safely over 50 ng/mL in about 4 hours. https://nutritionmatters.substack.com/p/calcifediol-to-boost-25-hydroxyvitamin
Proper individual and population-wide vitamin D supplementation is far safer and more beneficial than any vaccine. If the great majority of the population did this, there would be no epidemic transmission of SARS-CoV-2 or influenza at any time of year because most people would have mild or perhaps no symptoms, average levels of viral shedding would be much lower and so transmission would be much lower than at present. Those few infected would rarely be seriously harmed or killed.
If this sounds too simple to be true, please read the research articles mentioned above! Much of what I cite is cited by Prof. Sunil Wimalawansa (New Jersey) in his recent article: https://www.mdpi.com/2072-6643/14/14/2997 .
Serum Vit D is not an indication of the true levels in your body as it is stored in your body fats and released as needed. You can easily over-do it with Vit D supplementation and put your self on the path to arterial calcification.
Many doctors have overly-dramatic views on excessive 25-hydroxyvitamin D levels. They are basing their opinion and clinical advise on the what is written by committees, generally based on the faulty Institute of Medicine 2011 report: https://vitamindstopscovid.info/00-evi/#05-history . Doctors generally don't have the time or inclination to find and read the most pertinent research.
Please see all the research articles at that page, including the Holick et al. one from the Endocrine Society https://academic.oup.com/jcem/article/96/7/1911/2833671: "Although it is not known what the safe upper value for 25(OH)D is for avoiding hypercalcemia, most studies in children and adults have suggested that the blood levels need to be above 150 ng/mL [375 nmol/L] before there is any concern." This is very hard to attain.
Vit D is not a vitamin. It's a hormone. I get mine from sunshine and occasional cod liver oil. Makes an excellent rat poison due to it's ability to calcify rodent arteries. The insane practice of slathering carcinogenic sunscreens on one's body eliminates vit D synthesis and leads people to swallowing synthetic substitutes. As I said, blood levels don't indicate true levels in the body.
While there are likely to be significant health benefits from sun exposure of the skin, and of sunlight in general (via the eyes, affecting mood etc.) there are two major problems with relying on UV-B to produce sufficient vitamin D3 to attain, in general, at least 50 ng/mL 125 nmol/L circulating 25-hydroxyvitamin D. Firstly, unless special lamps are used, this is only naturally available, 30 or more degrees from the equator, in significant quantities in the middle of cloud-free summer days. Secondly, this ca. 297 nanometre UV-B light not only breaks a carbon-carbon bond in 7-dehyrocholesterol, to open up one of its four rings, with the resulting molecules isomerising to vitamin D3 cholecalciferol, it also damages DNA and so raises the risks of skin cancer. Also, people with brown or black skin would need an inordinate amount of UV-B to get the vitamin D3 they need.
Many people outside Australia don't think much about skin cancer, but it is a killer here. If everyone relied on UV-B to get the vitamin D they need, the skin cancer rates would skyrocket.
I don't know that physics has looked at different absorption for different skins in the UV-B. The reflection that is seen in the visible doesn't necessarily carry over to the ultraviolet. There would need to be studies done to find out whether different skins absorb UV-B differently.
A hormone is a substance which, by its concentration in the bloodstream, and perhaps the cerebrospinal fluid, affects the behaviour of cells which may be located anywhere in the body. It is a blood-borne long distance signaling molecule. This is endocrine signaling.
Of the three vitamin D compounds, only one ever acts as a hormone. Vitamin D3 cholecalciferol and 25-hydroxyvitamin D calcifediol never act as a hormone. Their level in the bloodstream does not signal anything. However, good levels, such as 50 ng/mL or more, of 25-hydroxyvitamin D are needed for many types of immune cell to work properly. They use it as a raw material to convert into 1,25-di-hydroxyvitamin D calcitriol, inside the cell, to activate vitamin D receptors also inside the cell. This is intracrine signalling, and it only happens when the cell detects a particular circumstance.
They kidneys also hydroxylate 25-hydroxyvitamin D to maintain a very low level of circulating (in the bloodstream) 1,25-dihydroxyvitamin D. This is the only instance in which 1,25-dihydroxyvitamin D acts as a hormone. The kidneys do this as part of a larger feedback system involving the parathyroid hormone, to regulate several aspects of calcium-phosphate-bone metabolism.
Vitamin D (here referring rather loosely to the three compounds collectively) based Intracrine (also known, not quite correctly, as "autocrine") signaling is internal to the particular cell - and is a crucial part of how some cell types respond to their individual circumstances. The concentration of 1,25-dihydroxyvitamin D which is produced, when the system is activated, is much higher than the very low level of hormonal 1,25-dihydroxyvitamin D. Except in pathological circumstances (granulomatous disorders such as sarcoidosis) this intracrine production of 1,25-dihydroxyvitamin D does not affect the kidney's control of the very low level of circulating, hormonal, 1,25-dihydroxyvitamin D. Some does diffuse from these cells, and to the extent it does, the kidneys would produce a little less to maintain the required calcium absorption in the gut and other aspects of calcium-phosphate-bone metabolism.
The generally stable, and very low, level of hormonal 1,25-dihydroxyvitamin D diffuses into cells, but this is too low a level to be mistaken for the activation of the intracrine signaling cascade.
Vitamin D based paracrine signaling involves some of this intracellularly produced 1,25-dihydroxyvitamin D (for, in part, intracrine purposes in the producing cell, or just for this paracrine purpose) diffusing into the interstitial fluid and being detected by other cell types, to change the behavior of nearby cells. So vitamin D based paracrine signaling is a short distance (millimetres, centimetres? I have never seen actual distance estimates) signaling system, unrelated to hormonal signaling, since the levels involved are higher in the localised areas where this occurs.
There is a trend to refer to "vitamin D" as a "hormone" as if this gives it a greater gravitas than if it was referred to as a mere "vitamin". However, this is untrue. See
You aren't seeing vitamin D quite accurately. There are two storage tanks of two different analogs of vitamin D--D3 is stored in adipose tissue and 25OHD is stored in the blood. D3 has no biological purpose and must be converted to 25OHD by the liver before it becomes useful.
There is some D3 released into the blood when D3 is produced by the body. There is competition from adipose tissue and the liver for the D3 in the blood.
I have spent a great deal of time at your vit. D websites and have learned a lot.
I have also done my own reading at google scholar and have brought my understanding of physics to bear, which is relevant to vit. D production from UV-B radiation. See my comment to Vinu about different skin types.
I have forwarded the link to Wimalawansa's article to my physician daughter.
I started taking Vit D after banned Drs told me to. I also started being out in sun more, shirt off... A beast, manufacturing Vit D and staying healthy.
Mr. Fauci and Mrs. Birx never mentioned it... Bitches
Indeed! Our orthopedist suggests we try to get our Vitamin D blood level to 80 or 85. Trying. At about 65 now. Some facts... 70% of people fall and break their hip. 30% of people break their hip and then fall. Almost all are profoundly Vitamin D deficient. I also take Super K to enhance D absorption. Malone, Mercola are good sources for information on vitamins as well.
🦋Every time there is a cheap, safe, readily available help, it is made illegal. I have my own secret remedies that are not illegal. Ivermectin is impossible to obtain in Australia so I figured out what is anti viral and anti inflammatory. Nasal and throat washes are very good with iodine or just clean anyway. Nose and throat is the first entry point of the virus.
Avoiding vaccine shedding is most important now, don’t get sucked in to catching vaccines and the cytotoxic spike protein through vaccine shedding! This possum, un conformist wears a spray painting respirator when shopping! 😱! So are dietary measures and Vit D etc. Never been vaxed or had C-19. It seems to work. Backyard “scientist” here 😎. Say no to peer group pressure🖕 and this will work magic. Trust yourself as if your life depended on it! 🦋
This action by vaccine makers, trusted doctors, and regulators is way more than duplicitous, it is criminal Have the class action lawsuits begun yet? They will. Lining one's own pockets and having obvious conflicts of interest makes the citizenry very angry.
Very good article thank you. On a side note, Cissus Quadrangularis (Grape leaf extract, used medicinally since antiquity) is an effective treatment and preventative for osteoporosis. It is also excellent for soft tissue injuries.
Not sure if I missed it in your article ... Is there a solution for sulfation when sunlight is not abundant (winter)? Sunlight is best of course. What's the alternative in winter?
While adequate vitamin D is important for reducing the risk of osteoporosis, boron is also important: https://aminotheory.com/cv19/#08-boron . Most people only get 1 mg or so boron a day, but 20 mg a day is safe for adults and 6 to 12 mg supplemental boron a day would probably significantly improve their bone health and help reduce excessive inflammation. Boron's biological mechanisms in mammals are not yet known.
Magnesium is also important, and very commonly not consumed in sufficient quantities. https://www.researchgate.net/publication/359772765_Long_Covid_Short_Magnesium
The 30 ng/mL 25-hydroxyvitamin D target and 0.025 to 0.05 mg 1000 to 2000 IU a day intakes mentioned above might be sufficient for the kidneys to supply the very low level of hormonal 1,25-dihydroxyvitamin D (calcitriol) needed for proper calcium-phosphate-bone metabolism, but these are inadequate for the immune system's needs - 50 ng/mL circulating 25-hydroxyvitamin D is needed. The immune system is not affected by nor does it affect the hormonal 1,25-dihydroxyvitamin D.
Please see the research articles cited at: https://vitamindstopscovid.info/00-evi/ .
Without proper supplementation, most people have only 5 to 25 ng/mL 25 hydroxyvitamin D, so their immune system's innate and adaptive responses are crippled - and they are at very high risk for wildly-dysregulated hyper-inflammatory responses.
For most 70 kg non-obese people, 0.125 mg 5000 IU vitamin D3 a day will attain at least 50 ng/mL 125 nmol/L after 3 months or so.
For rapid repletion of 25-hydroxyvitamin D in the event of COVID-19 or any other infection, 10 mg 400,000 IU vitamin D3 (for 70 kg BW) takes about 4 days to attain 50 ng/mL due to the need for hydroxylation in the liver. The best approach (again, 70 kg BW) is a single oral dose of 1 mg calcifediol (another name for 25-hydroxyvitamin D). This goes straight into circulation and raises levels safely over 50 ng/mL in about 4 hours. https://nutritionmatters.substack.com/p/calcifediol-to-boost-25-hydroxyvitamin
Proper individual and population-wide vitamin D supplementation is far safer and more beneficial than any vaccine. If the great majority of the population did this, there would be no epidemic transmission of SARS-CoV-2 or influenza at any time of year because most people would have mild or perhaps no symptoms, average levels of viral shedding would be much lower and so transmission would be much lower than at present. Those few infected would rarely be seriously harmed or killed.
If this sounds too simple to be true, please read the research articles mentioned above! Much of what I cite is cited by Prof. Sunil Wimalawansa (New Jersey) in his recent article: https://www.mdpi.com/2072-6643/14/14/2997 .
Serum Vit D is not an indication of the true levels in your body as it is stored in your body fats and released as needed. You can easily over-do it with Vit D supplementation and put your self on the path to arterial calcification.
Many doctors have overly-dramatic views on excessive 25-hydroxyvitamin D levels. They are basing their opinion and clinical advise on the what is written by committees, generally based on the faulty Institute of Medicine 2011 report: https://vitamindstopscovid.info/00-evi/#05-history . Doctors generally don't have the time or inclination to find and read the most pertinent research.
Please see all the research articles at that page, including the Holick et al. one from the Endocrine Society https://academic.oup.com/jcem/article/96/7/1911/2833671: "Although it is not known what the safe upper value for 25(OH)D is for avoiding hypercalcemia, most studies in children and adults have suggested that the blood levels need to be above 150 ng/mL [375 nmol/L] before there is any concern." This is very hard to attain.
Vit D is not a vitamin. It's a hormone. I get mine from sunshine and occasional cod liver oil. Makes an excellent rat poison due to it's ability to calcify rodent arteries. The insane practice of slathering carcinogenic sunscreens on one's body eliminates vit D synthesis and leads people to swallowing synthetic substitutes. As I said, blood levels don't indicate true levels in the body.
Agree that sunshine is the best source, when available. People with darker skin living in high latitudes are forced to use supplements.
While there are likely to be significant health benefits from sun exposure of the skin, and of sunlight in general (via the eyes, affecting mood etc.) there are two major problems with relying on UV-B to produce sufficient vitamin D3 to attain, in general, at least 50 ng/mL 125 nmol/L circulating 25-hydroxyvitamin D. Firstly, unless special lamps are used, this is only naturally available, 30 or more degrees from the equator, in significant quantities in the middle of cloud-free summer days. Secondly, this ca. 297 nanometre UV-B light not only breaks a carbon-carbon bond in 7-dehyrocholesterol, to open up one of its four rings, with the resulting molecules isomerising to vitamin D3 cholecalciferol, it also damages DNA and so raises the risks of skin cancer. Also, people with brown or black skin would need an inordinate amount of UV-B to get the vitamin D3 they need.
Many people outside Australia don't think much about skin cancer, but it is a killer here. If everyone relied on UV-B to get the vitamin D they need, the skin cancer rates would skyrocket.
In https://vitamindstopscovid.info/00-evi/#08-misinf I cite Miyauchi and Nakajima 2016 https://onlinelibrary.wiley.com/doi/10.1111/php.12651 who state that in a given day, vitamin D production in white skin cannot be increased by exposing the skin to more than about 1/3 the UV-B required to cause the skin to become a little pink.
I don't know that physics has looked at different absorption for different skins in the UV-B. The reflection that is seen in the visible doesn't necessarily carry over to the ultraviolet. There would need to be studies done to find out whether different skins absorb UV-B differently.
A hormone is a substance which, by its concentration in the bloodstream, and perhaps the cerebrospinal fluid, affects the behaviour of cells which may be located anywhere in the body. It is a blood-borne long distance signaling molecule. This is endocrine signaling.
Of the three vitamin D compounds, only one ever acts as a hormone. Vitamin D3 cholecalciferol and 25-hydroxyvitamin D calcifediol never act as a hormone. Their level in the bloodstream does not signal anything. However, good levels, such as 50 ng/mL or more, of 25-hydroxyvitamin D are needed for many types of immune cell to work properly. They use it as a raw material to convert into 1,25-di-hydroxyvitamin D calcitriol, inside the cell, to activate vitamin D receptors also inside the cell. This is intracrine signalling, and it only happens when the cell detects a particular circumstance.
They kidneys also hydroxylate 25-hydroxyvitamin D to maintain a very low level of circulating (in the bloodstream) 1,25-dihydroxyvitamin D. This is the only instance in which 1,25-dihydroxyvitamin D acts as a hormone. The kidneys do this as part of a larger feedback system involving the parathyroid hormone, to regulate several aspects of calcium-phosphate-bone metabolism.
Vitamin D (here referring rather loosely to the three compounds collectively) based Intracrine (also known, not quite correctly, as "autocrine") signaling is internal to the particular cell - and is a crucial part of how some cell types respond to their individual circumstances. The concentration of 1,25-dihydroxyvitamin D which is produced, when the system is activated, is much higher than the very low level of hormonal 1,25-dihydroxyvitamin D. Except in pathological circumstances (granulomatous disorders such as sarcoidosis) this intracrine production of 1,25-dihydroxyvitamin D does not affect the kidney's control of the very low level of circulating, hormonal, 1,25-dihydroxyvitamin D. Some does diffuse from these cells, and to the extent it does, the kidneys would produce a little less to maintain the required calcium absorption in the gut and other aspects of calcium-phosphate-bone metabolism.
The generally stable, and very low, level of hormonal 1,25-dihydroxyvitamin D diffuses into cells, but this is too low a level to be mistaken for the activation of the intracrine signaling cascade.
Vitamin D based paracrine signaling involves some of this intracellularly produced 1,25-dihydroxyvitamin D (for, in part, intracrine purposes in the producing cell, or just for this paracrine purpose) diffusing into the interstitial fluid and being detected by other cell types, to change the behavior of nearby cells. So vitamin D based paracrine signaling is a short distance (millimetres, centimetres? I have never seen actual distance estimates) signaling system, unrelated to hormonal signaling, since the levels involved are higher in the localised areas where this occurs.
There is a trend to refer to "vitamin D" as a "hormone" as if this gives it a greater gravitas than if it was referred to as a mere "vitamin". However, this is untrue. See
Reinhold Vieth "Why 'Vitamin D' is not a hormone, and not a synonym for 1,25-dihydroxy-vitamin D, its analogs or deltanoids" 2004 https://sci-hub.se/10.1016/j.jsbmb.2004.03.037 and my explanations of vitamin D based intracrine and paracrine signaling: https://vitamindstopscovid.info/00-evi/#02-compounds and https://vitamindstopscovid.info/02-intracrine/ .
You aren't seeing vitamin D quite accurately. There are two storage tanks of two different analogs of vitamin D--D3 is stored in adipose tissue and 25OHD is stored in the blood. D3 has no biological purpose and must be converted to 25OHD by the liver before it becomes useful.
There is some D3 released into the blood when D3 is produced by the body. There is competition from adipose tissue and the liver for the D3 in the blood.
I have spent a great deal of time at your vit. D websites and have learned a lot.
I have also done my own reading at google scholar and have brought my understanding of physics to bear, which is relevant to vit. D production from UV-B radiation. See my comment to Vinu about different skin types.
I have forwarded the link to Wimalawansa's article to my physician daughter.
I started taking Vit D after banned Drs told me to. I also started being out in sun more, shirt off... A beast, manufacturing Vit D and staying healthy.
Mr. Fauci and Mrs. Birx never mentioned it... Bitches
Indeed! Our orthopedist suggests we try to get our Vitamin D blood level to 80 or 85. Trying. At about 65 now. Some facts... 70% of people fall and break their hip. 30% of people break their hip and then fall. Almost all are profoundly Vitamin D deficient. I also take Super K to enhance D absorption. Malone, Mercola are good sources for information on vitamins as well.
Eating vitamin D with a high fat meal will enhance absorption. D3 is soluble in oils and lipids.
agree. and also we are taking Vitamin K2 to enhance D3 absorption.
🦋Every time there is a cheap, safe, readily available help, it is made illegal. I have my own secret remedies that are not illegal. Ivermectin is impossible to obtain in Australia so I figured out what is anti viral and anti inflammatory. Nasal and throat washes are very good with iodine or just clean anyway. Nose and throat is the first entry point of the virus.
Avoiding vaccine shedding is most important now, don’t get sucked in to catching vaccines and the cytotoxic spike protein through vaccine shedding! This possum, un conformist wears a spray painting respirator when shopping! 😱! So are dietary measures and Vit D etc. Never been vaxed or had C-19. It seems to work. Backyard “scientist” here 😎. Say no to peer group pressure🖕 and this will work magic. Trust yourself as if your life depended on it! 🦋
Our lives DO depend on it.
May you live long, outliving them and annoy them 🔱.
This action by vaccine makers, trusted doctors, and regulators is way more than duplicitous, it is criminal Have the class action lawsuits begun yet? They will. Lining one's own pockets and having obvious conflicts of interest makes the citizenry very angry.
Thank you for this great post. "willful misconduct" is putting it nicely.
Understanding that scientists are a group in its own league it is still very difficult
to accept that so many are so corrupt.
It's worse than most realize: vaccinesandmicroscopes.wordpress.com/
See also:
https://youarebeingliedto.substack.com/p/shot
Very good article thank you. On a side note, Cissus Quadrangularis (Grape leaf extract, used medicinally since antiquity) is an effective treatment and preventative for osteoporosis. It is also excellent for soft tissue injuries.
https://www.scitechnol.com/peer-review/role-of-cissus-quadrangularis-in-the-treatment-of-osteoporosis-a-review-TNBr.php?article_id=7876
p.s. I only trust PubMed articles published before 2020, after that I am very cautious and discerning when reading! Older the better
Agree. 1980s may be better than 2020 to draw the line!
Sooooo true!!
Thank you. Much appreciated.
This has been in the works (I mean control of nutrition by pharma) for a very long time. A bit of history.
https://thenhf.com/codex/
Sulfation, a necessary metabolic process, of D3 doesn't happen when we take supplements:
https://romanshapoval.substack.com/p/why-vitamin-d-supplements-dont-work
Love your analysis!
Not sure if I missed it in your article ... Is there a solution for sulfation when sunlight is not abundant (winter)? Sunlight is best of course. What's the alternative in winter?
Happy to find your great articles here on the Stack - thank you!!
This may be of interest:
https://vinuarumugham.substack.com/p/pharmas-war-on-cheap-medicines-killed/comment/14494659
May be he is trying to get some Democrat votes ...