Jul 1, 2022Liked by Vinu Arumugham #Kennedy24

I have a very basic question. What is the evolutionary purpose behind anaphylaxis?

I understand this:

"At the first injection, the organism was taken by surprise and did not resist. At the second injection, the organism mans its defences and answers by the anaphylactic shock."

But I don't understand why throat-closing symptoms would improve your odds of survival or reduce the threat you were sensitized to. For example, why does your blood pressure drop? Why constrict bronchioles?

"...The animal will rapidly develop severe vascular shock and die within a few minutes...

- combination of venule constriction and

- capillary dilation

- results in pooling of blood in the peripheral circulation

- drastic drop in blood pressure.

If exposed to the aerosol, it will equally...

- rapidly die from

- bronchial constriction."

Expand full comment

The calculated probabilities appear to be incorrect. For 4 vs. 1 events with large nearly-equal populations, the R language gives a p-value of 0.37 or 37%, far from the 1.5% claimed above.

prop.test(c(1, 4), c(21920,21920))

For 7 vs. 1 event the p-value is 0.077.

R is well vetted, and the documentation page cites references.


There is even an online version of R: https://www.mycompiler.io/new/r

Expand full comment